Supramolecular chemistry at interfaces Host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica
Title: Supramolecular chemistry at interfaces Host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica Authors: Tran, T.V. Vo, U.V. Pham, D.Y., (...) Thu, L.V. Nguyen, D.H. Keywords: 5-fluorouracil;cancer therapy;drug delivery systems;porous nanosilica Issue Date: 2016 Publisher: Walter de Gruyter GmbH Citation: Scopus Abstract: Porous nanosilica (PNS) has been attracting much attention in fabrication of nanocarriers for a drug delivery system (DDS). However, the unmodified PNS-based carriers exhibited a significant initial burst release of drug, which may limit their potential clinical application. In this study, PNS was surface conjugated with cyclodextrin (CD) which was functionalized with adamantylamine-polyethylene glycol (APEG) for 5-fluorouracil (5-FU) delivery, in which case CD was used due to its ability to form a stable inclusion complex with 5-FU and APEG. The conjugated PNS (P...